高遷移率族蛋白1(HMGB1)檢測(cè)試劑盒(化學(xué)發(fā)光免疫分析法)
CLIA Kit for High Mobility Group Protein 1 (HMGB1)
HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein
- 編號(hào)USCA399Hu
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 實(shí)驗(yàn)方法雙抗夾心
- 反應(yīng)時(shí)長(zhǎng)2h, 40min
- 檢測(cè)范圍13.7-10000pg/mL
- 靈敏度最小可檢測(cè)劑量小于等于5.1pg/mL.
- 樣本類型serum, plasma and other biological fluids
- 下載 英文說(shuō)明書 中文說(shuō)明書
- 規(guī)格 48T96T 96T*5 96T*10 96T*100
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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實(shí)驗(yàn)結(jié)果圖
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標(biāo)準(zhǔn)曲線圖
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通過(guò)ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
特異性
本試劑盒用于檢測(cè)高遷移率族蛋白1(HMGB1)，經(jīng)檢測(cè)與其它相似物質(zhì)無(wú)明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來(lái)源的限制，不可能完成對(duì)所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測(cè)，因此本試劑盒有可能與未經(jīng)檢測(cè)的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的高遷移率族蛋白1(HMGB1)（加標(biāo)樣品），重復(fù)測(cè)定并計(jì)算其均值，回收率為測(cè)定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 88-95 | 91 |
| EDTA plasma(n=5) | 96-105 | 101 |
| heparin plasma(n=5) | 80-91 | 87 |
精密度
精密度用樣品測(cè)定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對(duì)低、中、高值定值樣本進(jìn)行定量檢測(cè),每份樣本連續(xù)測(cè)定20 次，分別計(jì)算不同濃度樣本的平均值及SD值。
批間差：選取3個(gè)不同批次的試劑盒分別對(duì)低、中、高值定值樣本進(jìn)行定量測(cè)定，每個(gè)樣本使用同一試劑盒重復(fù)測(cè)定8次，分別計(jì)算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的高遷移率族蛋白1(HMGB1)，并倍比稀釋成1:2，1:4，1:8，1:16的待測(cè)樣本，線性范圍即為稀釋后樣本中高遷移率族蛋白1(HMGB1)含量的測(cè)定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 85-93% | 94-101% | 87-98% | 92-105% |
| EDTA plasma(n=5) | 85-94% | 95-102% | 90-101% | 80-101% |
| heparin plasma(n=5) | 92-103% | 85-104% | 85-95% | 83-92% |
穩(wěn)定性
經(jīng)測(cè)定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對(duì)試劑盒破壞前后檢測(cè)值的影響，實(shí)驗(yàn)室的環(huán)境條件需盡量保持一致，尤其是實(shí)驗(yàn)室內(nèi)溫度、濕度及溫育條件。其次由同一實(shí)驗(yàn)員來(lái)進(jìn)行操作可減少人為誤差。
實(shí)驗(yàn)流程
1. 實(shí)驗(yàn)前標(biāo)準(zhǔn)品、試劑及樣本的準(zhǔn)備；
2. 加樣（標(biāo)準(zhǔn)品及樣本）100µL，37°C孵育1小時(shí)；
3. 吸棄，加檢測(cè)溶液A100μL，37°C孵育1小時(shí)；
4. 洗板3次；
5. 加檢測(cè)溶液B100µL，37°C孵育30分鐘；
6. 洗板5次；
7. 加底物100µL，37°C孵育10分鐘；
8. 讀數(shù)。
實(shí)驗(yàn)原理
將高遷移率族蛋白1(HMGB1)抗體包被于96孔微孔板中，制成固相載體，向微孔中分別加入標(biāo)準(zhǔn)品或標(biāo)本，其中的高遷移率族蛋白1(HMGB1)與連接于固相載體上的抗體結(jié)合，然后加入生物素化的高遷移率族蛋白1(HMGB1)抗體，將未結(jié)合的生物素化抗體洗凈后，加入HRP標(biāo)記的親和素，再次徹底洗滌后加入底物。加入底物后會(huì)產(chǎn)生輝光型光信號(hào)。發(fā)射光強(qiáng)度和樣品中的高遷移率族蛋白1(HMGB1)呈正相關(guān)。用化學(xué)發(fā)光儀測(cè)定相對(duì)光單位（RLU），計(jì)算樣品濃度。
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| 編號(hào) | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| UAPA399Hu02 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UEPA399Hu62 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu63 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu61 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| URPA399Hu02 | 高遷移率族蛋白1(HMGB1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UAPA399Hu64 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu61 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu62 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu63 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| URPA399Hu01 | 高遷移率族蛋白1(HMGB1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu64 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UPAA399Hu06 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC; IP. |
| UPAA399Hu01 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC/IF |
| UPAA399Hu02 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC/IF |
| ULAA399Hu71 | 高遷移率族蛋白1(HMGB1)多克隆抗體(生物素標(biāo)記) | IHC |
| ULAA399Hu81 | 高遷移率族蛋白1(HMGB1)多克隆抗體(異硫氰酸熒光素標(biāo)記) | WB; IHC; ICC; IF. |
| UMAA399Hu23 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | ICC/IF |
| UMAA399Hu24 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu25 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu27 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu22 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | WB; ICC/IF |
| UMAA399Hu21 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | WB; IHC |
| USEA399Hu | 高遷移率族蛋白1(HMGB1)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| UIEA399Hu | 高遷移率族蛋白1(HMGB1)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法,快捷型) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| UAEA399Hu | 抗高遷移率族蛋白1抗體(Anti-HMGB1)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antibody Detection. |
| USCA399Hu | 高遷移率族蛋白1(HMGB1)檢測(cè)試劑盒(化學(xué)發(fā)光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| ULMA399Hu | 高遷移率族蛋白1(HMGB1)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| UKSA399Hu01 | 高遷移率族蛋白1(HMGB1)檢測(cè)試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法) | 自己動(dòng)手制作ELISA試劑盒的主要材料 |
| UPGA399Hu01 | 高遷移率族蛋白1(HMGB1)引物對(duì) | PCR |
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| Molecular Medicine Reports | Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury [pubmed:28627643] |
| Cell?Death?&?Disease | AMP-activated protein kinase agonist N 6-(3-hydroxyphenyl) adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis [Articles:s41419-017-0118-0] |
| Journal of Molecular?Cell?Biology | S1 PR 3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen‐glucose deprivation‐induced neuroinflammation via inhibiting TLR 2/4‐NF κB?… [Pubmed:29536648] |
| Frontiers in Immunology | Glycyrrhizin Protects Mice against Experimental Autoimmune Encephalomyelitis by Inhibiting HMGB1 Expression and Neuronal HMGB1 Release [Pubmed:30013568] |
| Oncoimmunology | Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune?… [Pubmed:29399399] |
| Cancer Immunology, Immunotherapy | Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer [Pubmed:29600445] |
| Cytokine | Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in?… [Pubmed:29895396] |
| Frontiers in Neurology | Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB?… [Pubmed:29867706] |
| Biomedicine & Pharmacotherapy | Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death [Pubmed:29958141] |
| Inflammation?Research | Luteolin activates ERK1/2- and Ca-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and?… [Pubmed:29497773] |
| Journal of?Food?and?Drug?Analysis | Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice [Pubmed:29389558] |
| Biochemical and Biophysical?Research?Communications | Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice [Pubmed:29680657] |
| Neurological Sciences | Thrombomodulin, alarmin signaling, and copeptin: cross-talk between obesity and acute ischemic stroke initiation and severity in Egyptians [Pubmed:29637447] |
| International Journal of Gynecology & Obstetrics | Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia [Pubmed:29569400] |
| Advances in Experimental?Medicine?and?Biology | Molecules of Damage-Associated Patterns in Bronchoalveolar Lavage Fluid and Serum in Chronic Obstructive Pulmonary Disease [Pubmed:29429028] |
| Taiwanese Journal of Obstetrics & Gynecology | HMGB1-RAGE signaling pathway in pPROM [Pubmed:29673663] |
| Chronic obstructive pulmonary disease (COPD)--from biomarkers to clinical phenotypes [ISBN:978-951-51-4039-5] | |
| Journal?of?Pharmacological?Sciences | Butyrate suppresses abnormal proliferation in colonic epithelial cells under diabetic state by targeting HMGB1 [Doi: 10.1016/j.jphs.2018.07.012] |
| Biomaterials Science | Delivery of 5'-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer Immunotherapy [Doi: 10.1039/C8BM01064A?] |
| iris-AperTO [] | |
| Toxicological Sciences | Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation [Pubmed: 31020321] |
| Molecular Medicine | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic?… [Pubmed: 31215394] |
| international immunopharmacology | Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes [Pubmed: 31185450] |
| Food & Function | Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats [Pubmed: 31140472] |
| International Immunopharmacology | BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma [Pubmed: 31600692] |
| Experimental and Therapeutic Medicine | High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support [Pubmed: 31602200] |
| Oxidative Medicine and Cellular Longevity | Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters?… [Pubmed: 31737175] |
| Pathobiology | Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle [Pubmed: 31722347] |
| Canadian Journal of Physiology and Pharmacology | Suppression of high-mobility group box 1 ameliorates xerostomia in a sjogren syndrome-triggered mouse model [Pubmed: 31935120] |
| Neurotoxicity Research | HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway [Pubmed: 31858421] |
| Journal of Clinical Medicine | Damage-Associated Molecular Patterns and Th-Cell-Related Cytokines Released after Progressive Effort [Pubmed: 32210109] |
| Journal of Immunology Research | Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro [Pubmed: 31886313] |
| urologic oncology | A novel diagnostic tool for the detection of bladder cancer: Measurement of urinary high mobility group box-1 [Pubmed: 32312640] |
| International Journal of Environmental Research and Public Health | Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent [Pubmed: 32316587] |
| VETERINARY MICROBIOLOGY | Upregulation of HMGB1 Secretion in Lungs of Pigs Infected by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus [Pubmed: 33221069] |
| Lab Invest | Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis [Pubmed: 32709888] |
| American Journal of Translational Research | Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and … [Pubmed: 32509190] |
| STEM CELL REVIEWS AND REPORTS | A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem … [Pubmed: 32406006] |
| Translational Stroke Research | Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting?… [] |
| stem cells international | Hypoxic Wharton's Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells [] |
| Frontiers in Cell and Developmental Biology | Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies [] |
| Naja sumatrana venom cytotoxin, sumaCTX exhibits concentration-dependent cytotoxicity via caspase-activated mitochondrial-mediated apoptosis without?… [] | |
| Journal of Burn Care & Research | Umbilical cord mesenchymal stem cells (hUCMSCs) for inflammatory regulation after excision and grafting of severe burn wounds in rats [33313794] |
| Cell Death & Disease | DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities [33504767] |
| Cells | Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death [32331368] |
| Infect Immun | A non-lethal murine flame burn model leads to a transient reduction in host defenses and enhanced susceptibility to lethal Pseudomonas aeruginosa infection [34152806] |
| Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury [34616852] | |
| Mol Cell Biochem | Autophagy-associated HMGB-1 as a novel potential circulating non-invasive diagnostic marker for detection of Urothelial Carcinoma of Bladder [34796446] |
| World J Gastroenterol | Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation [34908806] |
| Endocr J | Clinical significance of high mobility group box 1/toll-like receptor 4 in obese diabetic patients [34657898] |
| Research in Veterinary Science | Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally–Induced endotoxic shock [34715589] |
| Sci Rep | Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells [Pubmed:35058496] |
| ORL J Otorhinolaryngol Relat Spec | High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis [Pubmed:34979505] |
| J Exp Clin Cancer Res | SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma [Pubmed:35197103] |
| Am J Physiol Gastrointest Liver Physiol | Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms [Pubmed:35638693] |
| Journal of the South African Veterinary Association | Circulating markers of endothelial activation in canine parvoviral enteritis [] |
| Reseach square | The antiviral action of resveratrol against Zika virus through the regulation of interferon responses by HMGB1 [] |
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